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Even if the creation of mouse models for age-related multimorbidity proves too difficult, mice could still be used in initial testing, to confirm how a candidate geroprotector works, to observe the effect of a drug on tissue dysfunction and to study individual diseases in isolation.
Since the set of genotypes used in this study has been completely sequenced for SNP markers, the phenotypic information on root growth and drought avoidance responses presented here could be used in initial analysis of the genetic basis of dehydration avoidance traits and in facilitating improvement in drought resistance in rice.
However, all strategies assumed a limited antiviral drug stockpile (≈0.2 million courses) to be used in initial containment efforts for treatment of clinical case-patients and prophylaxis of case-patient contacts.
Completion of the symptom questionnaire on the website by patients at home provides a prediction of the likelihood of CTS which is sufficiently accurate to be used in initial planning of investigation and treatment.
The sequences annotated as USP did not form a monophyletic group in any of our analyses and to what extent USP should be used in initial annotation for this type of arthropod sequences could be questioned.
Nevertheless, it has been shown that carefully optimised heuristics combining exact and probabilistic matching can be used to generate large databases of healthcare records with good performance[ 8], especially when good quality unique identifiers (e.g. NHS number) can be used in initial linkage steps.
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All predictor variables were used in initial model building.
Murine mAbs were used in initial clinical trials.
These parasites are used in initial drug and small molecule inhibitor (SMI) screens in order to determine their in vivo anti-malarial activity in cultured cells and in mice.
To generate the Y764F mutant, primer pairs Y764F F2/R3 and F3/Y764F R2 were used in initial PCR reactions and the resulting PCR products further amplified with oligonucleotides F3 and R3.
Data from the cross-sectional U.S. National Health and Nutrition Examination Survey NHANESS) 2003 2006 were used in initial analysis (6).
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