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It does not produce persistent binding of the mu receptor, which would prevent the action of other opioids in acute and chronic painful conditions (Walsh et al 1995); as a result other opioids can be used for breakthrough pain in the presence of buprenorphine (Budd and Collett 2003).
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A small volume containing the majority of the eluted Ga can be used for research; however, the breakthrough of Germanium-68 (Ge) and other metals or chemical impurities may hinder the complexation if the generator matrix is eluted over a prolonged duration.
These breakthrough curves can be used for calculation of height of a practical exchange plate (HPEP) for design purposes.
Such a definition is used for viral breakthrough under the antiviral therapy of chronic hepatitis B. The natural course of HBV chronic hepatitis shows waxing and waning of HBV DNA levels within the range of <2 log10 copies/mL.
Finally, the obtained diffusion coefficients were used for the simulation of the breakthrough curves on column filtration experiments.
Column breakthrough experiments were used for studying the effect of the foulant on resin performance.
The transient breakthrough curves shown in Fig. 5 were used for model calibration.
Although luteinising hormone-releasing hormone (LHRH) agonists have been used for many years as ADT, they may be associated with clinical flare and testosterone breakthrough.
Because of its shorter duration of action it is prudent to administer this drug via PCA; nevertheless it can be used intravenously for breakthrough pain.
Amanda Feilding, founder of Beckley and co-director of the trial programme with Nutt, said: "The results from our research are helping is to understand how psychedelics change consciousness, and how this information can be used to find breakthrough treatments for many of humanity's most intractable psychiatric disorders, such as depression, addiction and obsessive compulsive disorder".
The model presented can be used satisfactorily in predicting breakthrough curves for two-component simultaneous and counter-current adsorptions of phenols on activated carbon in fixed beds.
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