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Expression of various matrix metalloproteinases has been found to be upregulated in virtually every type of human cancer, and this upregulation correlates with advanced stage, invasive and metastatic properties, and poor prognosis in general [ 113].
MMP-9 is a protease found to be upregulated in virtually all malignant tumors.
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MicroRNA-21, with chromosomal location 17q23.2, is upregulated in virtually all malignant neoplasms and with oncogenic functions related to all the hallmarks of a malignant cell (Zhu et al, 2008; Slaby et al, 2009).
MnSOD is upregulated in most CRC cells.
TRF1 expression seems to be upregulated in the G2/M phase.
MIF and OPN are two cytokines that were reported to be upregulated in hypoxic conditions77, 78.
SRF was shown to be upregulated in treated eyes versus control eyes of myopic guinea pigs35.
Ubiquitin pathway genes tend to be upregulated in cancer mediated by diverse mechanisms.
The results of screening revealed that virtually all genes presented on panel were upregulated in HF-derived samples.
Stx1 genes, stx1A and stx1B, were upregulated in the clade 2 strains that harbor the Stx1-converting phage (Supplemental Table S1), a result that was expected given that virtually all clade 8 strains examined in a prior study lacked stx1 [5].
Some sialidases are upregulated in lung fibrosis.
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