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Interferon alpha-inducible protein 27 (isI27) is an interferon alpha-inducible protein, which was found to be upregulated in some cancers, such as breast cancer, squamous cell carcinoma, hepatocellular carcinoma, and serous ovarian carcinoma.
Moreover, 1A6/DRIM has been found to be upregulated in some tumors (our unpublished data) and we are therefore currently investigating the 1A6/DRIM expression profile in human tumors to determine whether 1A6/DRIM can be used as a diagnostic marker or a therapeutic target in human tumors.
Differential display (DD) analysis revealed the expression of a gene encoding TCP-1 (t-complex polypeptide-1), the α subunit of CCT, in D. antiqua (DaTCP-1) to be upregulated in some tissues of pupae that exhibit enhanced cold hardiness [25].
However, the expression of MYO18A or MYO1E may be upregulated in some tumors.
This is consistent with the hypothesis that plasma membrane MRP-1 may be upregulated in some cancer cells.
Altered cellular morphology was further illustrated by the irregular distribution of αB-crystallin (Fig. 6G,Q), which appeared to be upregulated in some cells and not others.
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These data show that despite the variability in XIAP levels in the cell line panel, some patient samples show a marked upregulation of IAPs – and in fact multiple IAPs are upregulated in some cases (numbers 895, 1156).
At least CHIC2 expression was upregulated in some of the samples with underlying gene amplification.
Notably, it has been shown that RPL29 is upregulated in some malignancies.
Prior studies in other cancer entities have reported that ALCAM is upregulated in some and downregulated in others [ 8].
At the clinical level, as aforementioned, our current knowledge is that miR-10b is upregulated in some metastatic breast tumors.
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