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A variety of miRNAs in CAFs have been suggested to act as oncogenes and shown to be upregulated in certain cancers.
For example, Chiang et al recently used a mechanism-based inhibitor to inactivate and interrogate the physiological function of an integral membrane hydrolase (KIAA1363) that had been shown to be upregulated in certain aggressive cancers 68.
PRV-1 (CD177) is a hematopoietic cell surface receptor with yet unclear function normally expressed on neutrophils and can be upregulated in certain settings including, sepsis, pregnancy, and after granulocyte colony-stimulating factor administration.
Basal levels of Gas6 were low, yet it is known to be upregulated in certain states of intense inflammation such as septic shock and severe acute pancreatitis [ 19- 21].
Furthermore, miR-125b has been shown to be upregulated in certain leukemias [ 25- 27], gastric and follicular cancers [ 28, 29], pancreatic cancer [ 30] and some brain tumor derived glioma cell lines [ 31, 32].
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This signaling is upregulated in certain cancers.
Recent studies revealed that its expression is upregulated in certain types of cancer [7] [9].
They are upregulated in certain tumour types (Lowe and Lin, 2000).
Both Δ133p53 and Δ113p53 have been found to modulate p53 activity and Δ133p53 is upregulated in certain human cancers.
In accordance with the present findings, CB receptors were upregulated in certain tumour human malignancies, including oral squamous cell carcinoma, pancreatic, hepatocellular, and prostatic carcinoma, whereas they were not expressed in normal tissues of these organs [ 3– 6].
DNMT1 expression is upregulated in certain malignant blood cells [ 8, 9], and DNMT3A mutation is the most frequent novel genomic variation in acute myeloid leukemias (AMLs) identified and characterized by parallel sequencing technologies [ 10].
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