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FR is known to be upregulated in a cancer cells, whereas in normal cells, FR is only minimally distributed (Kamen and Smith 2004).
Preliminary studies indicate that NaK α1 subunits seem to be upregulated in a proportion of glioblastomas but not in normal brain tissues.
Five of the eight proteins were confirmed to be upregulated in a second independent set of ovarian cancer plasmas, including in early stage disease.
The MAGE family consists of related family members that are known to be upregulated in a variety of tumor types[18], but have recently been implicated in inducing transcriptional reprogramming in tumor cells[19].
RCAN1 has previously been shown to be upregulated in a variety of endothelial cell lines in response to VEGF, including human umbilical vein endothelial cells (HUVEC), human aortic endothelial cells (HAEC), human dermal microvascular endothelial cells (HDMEC), and human retinal endothelial cells (HREC) [10], [16], [17].
Both were confirmed to be upregulated in a panel of cell lines (Table 2).
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Hsf1 was very recently found to be upregulated in A. fumigatus under heat shock [ 18].
Autophagy can also be upregulated in an mTOR-independent manner by the disaccharide trehalose [ 64].
Furthermore, an orthologue (GenBank acc. No. AAEL006717) of human ABCB7 in the dengue vector, Aedes aegypti, was reported to be upregulated in an insecticide resistant strain [ 9, 63].
Additionally, miR172 was upregulated in A. thaliana [ 69] and B. distachyon [ 70].
The Ti concentrations in the brain were upregulated in a dose-dependent way.
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