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Similarly, EZH2 has recently been shown to be upregulated and active in SCLC [ 16, 17].
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Approximately equal numbers were upregulated and downregulated.
Of these, 49% were upregulated and 51% were downregulated.
Of these, 30 were upregulated and 13 downregulated (Table 2).
In a recent study, the complement component C1q in serum from patients with systemic lupus erythematosus was found to be upregulated, and further upregulated in patients with active disease [ 42].
Furthermore, EZH2 is upregulated in breast cancer, and high EZH2 levels are associated with aggressive breast cancer.
Abolishing Ets subfamily activity, which is upregulated downstream of Ras, rescues these phenotypes and blocks glioma initiation.
Although Grainy head signalling is active at low levels under physiological conditions to maintain epidermal integrity in both mammals [grainyhead-like 3 (Grhl3)] and Drosophila, these studies suggest that its activity is upregulated to drive the wound healing response.
Previous studies have shown that the mTOR pathway is constitutively active in serum-starved MiaPaCa-2 cells and that eIF4E is upregulated in PC compared with normal cells.
SSZ1 and UMP1 were upregulated 30%and10%0%, respectively (Table S1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com