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In reality, however, TCRs are not required to recognize HLA-bound peptides by sequence similarity but rather by peptide side chain accessibility., Consequently, the set of potential cross-reactive sequences is very likely dramatically greater and would be unwieldy in initial validation experiments.
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If the movie is unwieldy in places, it is completely alive.
Such an eigen decomposition is straightforward in theory but is unwieldy in practice, due to the extremely large number of possible states.
Often knowing what method to use is not obvious and their application can be unwieldy, especially in higher dimensions.
Multi-donor trust funds, in their current form, can be unwieldy and subject to long delays in initiation and work best when national governments are already strong.
A universal protocol for positional cloning in maize would be unwieldy because the steps taken will depend upon the particularities of the locus to be cloned.
Data are often presented in tabular form, which may be unwieldy for non-technical audiences.
This graphical representation could be unwieldy because of the shear number of higher-order correlators in the model.
Justice Kagan said that would be unwieldy.
People sure can be unwieldy.
However, those scales are unwieldy to use in clinical settings and they require cultural adaptation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com