Sentence examples for be unmethylated in normal from inspiring English sources

Promoter CpG islands have traditionally been thought to be unmethylated in normal cells.

Both KDM6A and KDM5C are located on the X chromosome and known to escape X-inactivation., Therefore, both alleles of KDM6A and KDM5C would be expected to be unmethylated in normal cells, as we observed (data not shown).

The majority of CpG of all amplicons were unmethylated in normal DNA, but showed different methylation patterns in MCL cell lines (Figure 1).

LINE-1 hypomethylation is not specific for cancer cells, and about one third of LINE-1 is unmethylated in normal mucosa and cancer mesenchymal cells [22], [23].

It was unmethylated in normal epithelial cells, as well as normal tissues, of breast and prostate, whereas in all the cancer cell lines examined the corresponding region was partially or entirely methylated.

Thus, the miR-200c cluster CpG island is unmethylated in normal miR-200c/miR-141-positive epithelial cells, while being densely methylated in the paired normal miR-200c/miR-141-negative miR-200c/miR-141-negative miR-200c/miR-141-negative miR-200c/miR-141-negative

Furthermore, TGFBI promoter methylation might be useful as a marker for malignant transformation because it was unmethylated in normal melanocytes and hypo- or fully methylated in freshly isolated primary and metastatic melanoma cells, as well as melanoma tumors.

Twenty genes out of 25 (80%) showed hypermethylation in at least one MCL cell line, whereas all of them (CDH1, AHR, CDC14B, CYB1B1, FOXC1, G0S2, GPX3, HOXA9, LGALS3, MAL, NPTX2, PAX6, PTPRG1, ROBO1, SOX9, TFPI2, THEM4, TWIST1, and NR2F2) but one (PEG3) were unmethylated in normal DNA.

In contrast, the region was unmethylated in normal thyroid tissues.

The entire CpG islands of both P3H2 and P3H3 were unmethylated in normal mammary epithelium.

In contrast, the CpG island was unmethylated in normal breast epithelium and the remaining cell lines examined.