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It is an essential part of the complex and it seems to be universally distributed among eukaryotes [51], [52].
Moreover, the predicted features seem to be universally distributed among sequences of a wide range of both Gram-negative and Gram-positive bacteria, regardless of the existence of a T3SS.
This enzyme may have become specialized posterior to the divergence of the LCA, from a broad-specificity ancestor, similar to the HGPRTase (PRTases) (2.4.2.8); indeed, this enzyme was found to be universally distributed among the three cellular domains and exhibits a similar catalytic mechanism.
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Roberts et al. [ 2] showed that the signatures are not limited to just entire domain specific ribosomal proteins, but can also take the form of domain specific insertions in the r-proteins that are universally distributed among all three domains of life.
These biomolecules are universally distributed in all living domains, present in high numbers in each cell, and are functionally conserved.
The Chordopoxvirinae are universally distributed and capable of infecting a wide range of avian, reptilian and mammalian species.
While several CYP450 genes are universally distributed, CYP19 is so far restricted to the vertebrate lineage.
From our analysis, we initially located 227 protein families that were universally distributed between all taxa.
GNATs are universally distributed in Nature and use an acyl-CoA to acylate their cognate substrates.
NTR is universally distributed from bacteria to mammals, but two different forms have evolved.
HMGB-1 in naïve HK-2 cells is universally distributed inside the nucleus.
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