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Our study may be underpowered to demonstrate a small effect.
Given the existing data the study may be underpowered to demonstrate small associations, which are not entirely unlikely given the existing results of genome-wide association studies.
The low incidence of deqi in tactile stimulation could also explain why in earlier studies with small sample sizes, the tactile stimulation control might be underpowered to demonstrate the deqi response and the hemodynamic response associated with it [ 7].
In addition, our study is likely to be underpowered to demonstrate any statistical difference in T2D risk according to the use of statins due to the short follow-up period.
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Finally, it is likely that the two studies were underpowered to demonstrate a difference in the principal endpoint.
The sample size was estimated based on the primary clinical outcome, and it is possible that it was underpowered to demonstrate a significant difference in cost-effectiveness.
Neoadjuvant chemoradiation (nCRT) is associated with higher pathologic complete response (pCR) relative to chemotherapy (nCTX), but has not been shown to improve survival; however, previous studies have been underpowered to demonstrate a survival difference.
One study, involving subjects aged ≥60 years, did not find an association between non-migraine headache and ischemic stroke; however, the number of included subjects in this study was low and it may have been underpowered to demonstrate a significant association [129].
But this trial was underpowered to demonstrate a significant effect on stroke and only followed patient outcomes for 11 days.
Therefore, the study may have been underpowered to demonstrate a significant effect of aspirin on the primary end point.
Upon exclusion of subjects with osteophytes, we may have been underpowered to demonstrate an association between BMLs and BMI.
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