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Although constitutive and alternative SSs showed no significant difference in our comparison (supplementary fig. S3, Supplementary Material online), a fraction of the alternative SSs may be under substantial selection for splicing regulation, possibly reducing the signal of positive selection.
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If any other traits were under substantial selection in primordial genomes, and these traits were not perfectly congruent with error minimization, then an evolutionary process favoring increased fitness would yield a sub-optimal genetic code.
This approach eliminates far more sequence for each HCV genome than is actually under immune selection in a given patient, but its advantage is that the remaining sequences are very unlikely to be under substantial immune selection.
Typically, a strong correlation between amino acid mutations is interpreted as evidence of functional interactions under substantial selection pressure.
In this regime, selection flips trigger adaptive substitutions, which occur at a rate γ L for independently evolving sites under substantial selection (Nf ≫ 1).
BHS is under substantial financial pressure.
Mr. Klock recalled things differently, saying that Ms. Harris was under substantial pressure from the Bush team.
The correlations between allele substitution effects and iHS among sites identified to be under selection however was substantial with 0.466 among the top 1% of sites and even higher among the top 0.1% of sites.
Absolute intercept values are between 1.0 and 2.0, which is consistent with substantial selection bias [22].
However, the interspecific FST of most SSR and AFLP loci exhibited very low values, suggesting substantial genetic exchanges at loci unlikely to be under disruptive selection (Fig. 8).
In particular, there are substantial differences in photosynthetic performance in Schiedea, suggesting that some of the protein coding genes involved in photosynthesis could be under positive selection.
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