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These results are consistent with the idea that the RBS of a gene might be under stronger selection to increase its openness with temperature.
It is easy to infer that the Asiatic honeybee may be under stronger selection to defend against pathogens and parasites than the Western honeybee.
Proteins that interact with the largest number of other proteins in the protein-protein interaction network could potentially buffer mutations at each interacting locus, and are therefore predicted to be under stronger selection to create robustness (Figure 1).
Additionally and/or alternatively, Asiatic honeybee adults may be under stronger selection pressure from pathogens and parasites, resulting in greater positive and diversifying selection on antimicrobial peptide sequences than in the Western honeybee.
Because mutations in the core regions are most likely to modulate TF-DNA interaction and subsequent transcription activity, we postulated that these regions may be under stronger selection than the full-length TFBSs considered above.
The direct selection hypothesis does not predict that ER will be strongly correlated with network structure, although we might expect to see some relationship due to the fact that highly connected proteins tend to be under stronger selection [29], though the correlation is relatively weak.
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Given these theoretical results, we expect mutational robustness to be typically weakly selected while environmental robustness should be under strong selection [10], [13], [16], [19] [22].
A. Once mate choice identifies a trait as informative about something, that trait is going to be under strong selection to amplify its appearance.
Males courting potentially sexually cannibalistic females may be under strong selection to bias their courtship efforts away from hungry females that may be more likely to attack.
This variation may seem surprising, as sperm should always be under strong selection to fertilize eggs.
In an antagonistic co-evolutionary arms race between host and pathogen, PCWDEs could be under strong selection.
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