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These genes are supposed to be under strong selective pressure (purifying selection) due to their important role in the timely removal of glutamate at the synapse.
In addition, the greater distance of LCRs to exons is also expected to result from relaxation of selection as previous studies reported sequences near introns to be under strong selective constraints due to the presence of splicing regulatory elements and to the deleterious effects of the disruption of these elements (Pagani et al. 2005; Parmley et al. 2006; Warnecke and Hurst 2007).
This genomic region is likely to be under strong selective pressure to maintain a tryptophan prototrophy.
Of these 35 genes, 15 were predicted to have lost the function of the encoded proteins and seven of the latter were found to be under strong selective pressure.
Transmission success is crucial to the parasite and gametocyte production has been repeatedly shown to be under strong selective pressure [32], thus making this stage of the lifecycle propitious for intervention.
The lag before bacteria cells start dividing is of particular interest to us, as it as proved to be under strong selective pressure in former work [15], [16], [19].
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This observation is in line with the fact that co-evolving proteins, if interacting physically, may be under stronger selective pressure to conserve.
Genes with more distinct functions may be expected to be under stronger selective constraint.
They would be under stronger selective pressure to consent to a miRNA cluster's regulation.
Therefore, single copy genes might be under stronger selective constraints [ 11].
Previous studies have reported that genes targeted by more miRNAs tend to be under stronger selective constraints [ 24- 26].
More suggestions(18)
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be under negative selective
be under different selective
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be under strong epigenetic
be under little selective
be under antibiotic selective
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be under divergent selective
be under dual selective
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be under direct selective
be under strong genetic
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