Sentence examples for be under strong functional from inspiring English sources

These findings are consistent with understandings of GPCR structure and function given that transmembrane domains are expected to be under strong functional constraint to maintain secondary structure and hydrophobicity.

Cold spots could also be under strong functional constraint, such that recombination is not tolerated (Nakamura et al. 2004).

Therefore, both coding and regulatory sequences are expected to be under strong functional constraints for these genes and, particularly, for the Hox1 genes whose appropriate regulation has been shown to be critical for development (Kmita and Duboule 2003).

Two possible evolutionary scenarios can explain this pattern: a) this is an old duplicate event, but the N-terminal extensions have a recent conversion or may be under strong functional constraint; and b) this is a young duplicate event, and the putative mature peptides evolved very fast.

Chu et al. (1994) found that although very low levels of DRA polymorphisms exist in mice, these molecules remain involved with peptide binding and suggested that the DRA is under strong functional constraints, such that any mutations would be deleterious to peptide-presenting function.

Using the functional residue information at the DDX3X ATPase site, we showed that most of these residues are under strong functional constraints and that validates their conservation pattern (Figure 3).

Our results suggest that the evolution of gene family size in Picea is under strong functional and selective constraints.

It is assumed that homologous segments that show significant similarity are under strong functional constraints, otherwise are evolving free from functional constraints.

Only 1.6%% of all codons appear to have evolved under positive selection, and approximately 69 % have been under strong functional constraints.

When considering hearing related genes, the average d N /d S rate genes is 0.12 ± 0.041 mean ± SD), suggesting that hearing related genes are under strong functional constraint.

Since Val316 and Lys764 residues are invariant from human to fish, this could suggest that these positions are under strong functional constraint.