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If the dN/dS rate ratio is <1, there is evidence for purifying (negative) selection, and the duplicated genes are thought to be under selective constraint.
The concept that some large fraction of some introns may be under selective constraint for a specific function does not negate the possibility that neutral segments of the same intron may be under selection for transcriptional efficiency.
Davydov, E. V. et al. Identifying a high fraction of the human genome to be under selective constraint using GERP++.
Davydov, E. V. et al. Identifying a high fraction of the human genome to be under selective constraint using GERP.
Thus the promoter region of sphinx seems to be under selective constraint.
The underlying assumption is that an accurate prediction algorithm should identify functionally important sites that are likely to be under selective constraint.
Similar(47)
Although nonsynonymous sites and RNAs are well known to be under selective constraints, the present study reveals selection on the D-loop region of mitochondrial genomes.
The results indicated that the putative HH motif in the pDo500 satDNA is likely to be under selective constraints and may be functional in Dolichopoda.
As the analysed transferrin locus is reported to be under selective constraints in salmonids [ 55], it was excluded in the estimation of the overall nucleotide diversity.
Based on such correlations, genome size was hypothesized to be under selective constraints (Gregory 2002); however, comparative studies in bacteria have failed to support such adaptive view as a general explanation.
M-type mtDNA evolves faster, but we do not think that this is because of a relaxed selection: M-type has to perform in very important contexts, such as gametogenesis and fertilization, so it has to be under selective constraints.
More suggestions(11)
maintained under selective constraint
be under weak constraint
be under strong constraint
be under selective neutrality
be under functional constraint
be under selective conservation
be under adaptive constraint
be under relaxed constraint
be under evolutionary constraint
be under selectional constraint
be under selective pressure
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