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Viruses might therefore be under selection pressure to adapt to the monomorphic proteasome and TAP.
In total, the Datamonkey server analysis indicated 37 codons to be under selection pressure.
Thus, the region around gp60 in subtype IbA10G2 might be under selection pressure.
None of the loci analyzed proved to be under selection pressure according to the Nei Gojobori method.
Many CDSs in this region were short CDSs that coded for hypothetical proteins, pseudogenes, and gene remnants, indicating that this region might no longer be under selection pressure.
The predicted stable secondary structures of ILEs seem to be under selection pressure as suggested by the many compensatory mutations observed in ILEs.
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These considerations indicate that the IG1 and S6 domains could indeed be under selection pressures distinct from those acting on other regions of DG.
Hosts are under selection pressure to evolve resistance against pathogens whereas pathogens are under selection pressure to evolve counter-resistance against the resistance mechanism of their host.
NLRs are highly variable in sequence, suggesting that they are under selection pressure, but also that they may be manipulated to generate proteins with new recognition specificities.
Of note is that the C3 region was under selection pressure in the infected infant from whom the BG505 virus was isolated.
In this way we estimated that on average 18% of the epitope precursors are under selection pressure in a host, i.e. are an actual epitope in that host.
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