Sentence examples for be under negative selection from inspiring English sources
Substitutions that deleteriously affect the affinity, specificity and selectivity of a beneficial motif will generally be under negative selection and will fail to spread through the population.
The authors also found a correlation between genes predicted to be under negative selection and genes implicated in certain hereditary diseases.
For example, among the genes the researchers predicted to be under negative selection are those involved in muscular dystrophy and in Usher syndrome, the most common cause of congenital blindness and deafness in developed countries.
Sebat et al.[12] suggests that CNVs might be under negative selection.
Most ZNFs appeared to be under negative selection pressure; there was little evidence of positive selection.
Interestingly, this residue was predicted by the REL method to be under negative selection.
In a long enough generation period, indels (or SNPs) with higher derived allele frequencies are more likely to be related to positive selections (adaptive selections), as those with lower derived allele frequencies tend to be under negative selections (purifying selections) for deleterious variants, in particular, the extremely rare variations.
At the individual codon level, we found 99 residues were under negative selection in MYB genes without a single positively selected residue.
They claim that the likely reason that these virulence factors are under negative selection is that they lead to immune evasion (the immune system targets the virulence factors).
It is clear that both CHR-O and N-CHR homologous groups are under negative selection.
