Exact(4)
Our study demonstrates the power of using the conservation of transcription factor binding at orthologous mouse-human genes as a tool to identify regulatory connections that appear to be under evolutionary pressure.
Some sites would be free to mutate to achieve increased stability, while others would be under evolutionary pressure to maintain a strict structure-function relationship.
The arrangement of r-proteins may be under evolutionary pressure that fine-tunes mass distributions for optimal structural dynamics and catalytic activity of the ribosome.
This may suggest that the promoter architecture of ORs may be under evolutionary pressure to drive transcription both in OE and in other tissues strongly challenging the idea that OR expression outside OE is "atypical" or "ectopic".
Similar(56)
Basically, they argue that birds are under evolutionary pressure to speed up embryonic development so vulnerable incubation time periods are shortened.
Pathogens constrained to survive within a mammalian host are under evolutionary pressure to acquire mechanisms that favor a chronic infection.
We define a TFBS as a locus that is under evolutionary pressure so the sequence is one that a particular transcription factor will bind to.
The G protein is under evolutionary pressure due to the host population adaptive immune response to this immunogenic region [45], [63] [66].
We suspect that HVR domains are under evolutionary pressure to adopt structurally stable folds despite sequence divergence.
are lowly or not expressed, suggesting that these cells are under evolutionary pressure to counteract viral but not bacterial infections, probably because they are seldom confronted by bacteria.
SH3 domains from other species that have not been under evolutionary pressure to ignore this site exhibit less selectivity for the Pbs1 peptide [ 83].
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