Sentence examples for be under evolutionary constraint from inspiring English sources
The recent analysis of DNA topography conservation, rather than nucleotide sequence, suggested that up to 12% of the human genome could be under evolutionary constraint [5].
Genome-wide analyses of non-coding evolutionary constraint in different taxa support this interpretation: only 5 percent of the basepairs in human non-coding DNA appear to be under evolutionary constraint [6], while approximately 50 percent of the twenty-fold smaller D. melanogaster genome is similarly constrained [7].
Positive scores suggest that a site may be under evolutionary constraint.
Due to their non-functional nature, pseudogenes are not expected to be under evolutionary constraint and instead, are expected to be under neutral selection.
Positive scores represent a substitution deficit and thus indicate that a site may be under evolutionary constraint, while negative scores indicate that a site is probably evolving neutrally.
The rationale for this approach is that interacting residues would necessarily be under evolutionary constraints due to the need to maintain compatibility with the corresponding partner motif and would therefore exhibit increased conservation [26].
We assess the evidence for recent purifying selection at lncRNA loci and compare the extent of selection at lncRNAs with functional loci known to be under evolutionary constraints, such as PC genes.
The rationale is that, if homologs of both partners are present in different species, it is likely that they interact in a similar manner and that the residues contributing to this interaction will be under evolutionary constraints that can be detected in the sequence alignment.
For the four remaining cases, an alternative hypothesis could be that the flanking LTRs are under evolutionary constraint or that the NRR regions actually contain uncharacterized repeats that were not detected during similarity searches.
For all three mutations we observe conservation scores close to 5.0, an indication that the positions are under evolutionary constraint.
