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The recent analysis of DNA topography conservation, rather than nucleotide sequence, suggested that up to 12% of the human genome could be under evolutionary constraint [5].
Our study demonstrates the power of using the conservation of transcription factor binding at orthologous mouse-human genes as a tool to identify regulatory connections that appear to be under evolutionary pressure.
The rationale for this approach is that interacting residues would necessarily be under evolutionary constraints due to the need to maintain compatibility with the corresponding partner motif and would therefore exhibit increased conservation [26].
Genome-wide analyses of non-coding evolutionary constraint in different taxa support this interpretation: only 5 percent of the basepairs in human non-coding DNA appear to be under evolutionary constraint [6], while approximately 50 percent of the twenty-fold smaller D. melanogaster genome is similarly constrained [7].
Positive scores suggest that a site may be under evolutionary constraint.
Sex chromosomes are considered to be under evolutionary constraints different from those of autosomes.
Similar(41)
Basically, they argue that birds are under evolutionary pressure to speed up embryonic development so vulnerable incubation time periods are shortened.
For the four remaining cases, an alternative hypothesis could be that the flanking LTRs are under evolutionary constraint or that the NRR regions actually contain uncharacterized repeats that were not detected during similarity searches.
Pathogens constrained to survive within a mammalian host are under evolutionary pressure to acquire mechanisms that favor a chronic infection.
We define a TFBS as a locus that is under evolutionary pressure so the sequence is one that a particular transcription factor will bind to.
The G protein is under evolutionary pressure due to the host population adaptive immune response to this immunogenic region [45], [63] [66].
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