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Differences in selective constraints between humans and animal models are also important for drug trials, where the drug target may be under different evolutionary dynamics in the animal model [10], [13].

In terms of molecular evolution, alternatively spliced exons and constitutively spliced exons are known to be under different evolutionary pressures.

Due to their special inheritance patterns, maternally and paternally expressed genes might be under different evolutionary pressure.

Female and male pheromones appear to have different origins and to be under different evolutionary constraints, thus they might be envisioned as independently evolving traits.

The presence of KLHL9, which appears to be under different evolutionary constraints than IFNW and IFNA, close to IFNA/IFNW cluster 2 suggested the cluster as whole might be under different evolutionary control than cluster 1 or 3. Evolutionary divergence rates do not indicate that this is the case, however (Table 3).

Long non-coding RNAs play diverse roles in biological processes but are thought to be under different evolutionary constraints and are expected to have low sequence conservation compared to protein-coding sequences [ 38], which has hampered the study of long non-coding RNA in vertebrates.

Similar(52)

On the assumption that sequences with potential RT activity may have been under different evolutionary constraints and may differ in their phylogenetic resolution, the sequences with no stop codons in the retrieved pol gene were analyzed separately from those with stop codons.

This suggests that the different domains of the TLR molecules are under different evolutionary pressures.

That mutations accumulate at different rates in the cluster III and cluster I type nitrogenases suggests that NifD is under different evolutionary constraints in these two groups.

Repetitive elements are under different evolutionary constraints as compared to genes, and are considered as fast-evolving components of eukaryotic genomes.

A comparative genomics approach based on homologous gene groups (HGGs) was undertaken to evaluate the extent to which secretome members are under different evolutionary constraints.

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