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Perhaps it's my years in the classroom, but I've always shied away from candidates who would probably be unable to substitute for me on a sick-day.
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It gives the offense a decided edge because defenses are unable to substitute players, either to keep them fresh or to get them into favorable matchups.
So there is no sense to defeat, as we defeated in several places, the organized crime if you are unable to substitute the corrupt law enforcement agencies with new policemen.
Each of these proteins is unable to substitute other metal ions for copper.
Furthermore, we find that Swf1 is highly specific for its substrates, as it is unable to substitute for other PATs.
However, the effect appears not to be mediated solely by PPARα and γ, because the PPARα activator fenofibrate was unable to substitute completely for RS.
While it is feasible that loss of one component or PRC1 complex could expose the locus to other influences, such as H3K27 histone demethylase activity, it is not clear why other complexes are unable to substitute.
ORFs 75a and 75b, although related in DNA sequence to ORF75c and also present in the tegument, were unable to substitute for it, indicating that their functions are distinct.
Furthermore, MyoD and Myf5 are unable to substitute myogenin's function during differentiation [ 11].
Results presented here indicate that PACT is unable to substitute for R2D2 at the whole organism level.
In yeast, mitochondrial genomes with >98% sequence identity are unable to substitute effectively for each other (Zeyl et al. 2005; Wei et al. 2007).
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