Ongoing quality assessments of medical reporting are required to ensure that the messages communicated are truly informative to lay and medical audiences alike.
For predicting the functional impact of variants in non-coding regions, the opposite is suggested, with fewer types of data being truly informative.
One of the reviewers suggested that you might use stepwise logistic regression as a way to select those variables that are truly informative.
However, dose titration does complicate analysis since only the stool diaries in the last 2 weeks are truly informative of the response, meaning that we cannot impute data to allow for incomplete diaries, which would be normal practice.
One can question whether static measurements of single or complex biomarkers are truly informative about health status, reasoning from the concept that health is defined by the ability to adequately adapt to everyday challenges.
It also included covariates that were selected in the majority of models on repeated random sub-samples of the data with the aim of identifying factors that were truly informative since repetition of the procedure allowed more of the data to be used for derivation of the models.
Note that, the adjective "non-informative" prior used in this paper is the classical wording but does not necessarily mean the prior is truly non-informative, as will be seen below.
