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Because older patients tend to be treated with multiple medications for multiple comorbidities, it becomes challenging to design regimens that avoid or reduce the risk of drug drug interactions.
This should be treated with multiple hypothesis testing.
Those with prodromal illness would be treated with multiple antibiotics, with regimens similar to those used for the anthrax attacks in the U.S. in 2001 [ 8].
Men are more exposed to be treated with multiple psychotropic medications and the diagnosis of the patient is the most reliable predictor for polypharmacy with these drugs.
The observed relationship between increased number of antihypertensive drugs and poorer BP control could be explained by the fact that patients whose BP is more difficult to control are likely to be treated with multiple drugs.
In 1 study, for example, patients that had greater severity of symptoms were more likely to be treated with multiple medications upon discharge from an inpatient psychiatric unit [ 14].
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In insulin-treated patients with T1DM, 23.3% were treated with conventional therapy, 66% were treated with multiple daily injections, and 10.7% were treated with CSII 1 year after diabetes diagnosis.
Women were treated with multiple insulin injections aiming at normoglycaemia.
They are currently being treated with multiple antibiotics and additional surgeries.
Male Sprague Dawley rats were treated with multiple doses of minocycline (45 mg/kg i.p).
A linear transfer function model comprising 4 parameters is used to describe the post-prandial breakfast excursions of a group of 10 type 1 diabetes patients who are treated with multiple daily insulin injections.
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