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Thus, in both methods, the groove can be treated at each instant as migrating at constant speed.
Cohorts of at least three patients were to be treated at each dose level.
Initial cohorts of three patients each were to be treated at each dose level, 0.5, 1.0, 1.5, 2.0, 3.0, and 3.5 mg/kg, infused over 2 h.
See Appendix D. Cohorts of 3 10 patients were to be treated at each dose level until the MTD was defined based on observance of DLTs; however, the MTD was not reached due to lack of DLT.
The protocol stipulated that at least three patients should be treated at each dose level, with a 1-week interval between entry of the first patient and the next two patients.
We did not restrict the analysis to any type of hospital (we included hospital fixed effects to allow for hospital differences), and we did not impose a minimum number of patients to be treated at each hospital (observations in the hospital level regressions were weighted by the number of patients).
Similar(52)
At least three patients were treated at each dose level.
Three patients were treated at each dose level.
Successive cohorts of at least three patients were treated at each dose level.
At least three assessable patients were treated at each dose level.
At least three patients were treated at each dose level in the first part (phase I).
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