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So what had the dogs actually learned — and how could that lesson be translated to human beings?
One caveat about the use of mice, transgenic or otherwise, is that uncertainties still exist regarding the degree to which cardiovascular phenomena, especially the pathobiology of atherosclerosis in these rodents, can be translated to human beings (see review in [ 87]).
Next, we wondered whether the mechanism underlying IFN-γ-induced TRC dormancy was universal and could be translated to human TRCs.
Finally, we demonstrated that such a technique could be translated to human cardiomyocytes derived from induced pluripotent stem cells to construct endothelialized human myocardium.
Currently, it is not clear whether such findings can be translated to human sepsis.
To be able to test these drugs that will later be translated to human clinical trials for OA, experimental dose levels of new therapies are calculated based on cartilage volumes of the target species and breed.
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However, despite the large number of investigations made, the results obtained in animal models are still hard to be translated to humans; therefore there is a critical need for continued translational research and animal studies to improve our understanding of the molecular mechanisms that underlie the cardiac dysfunction of antiblastic drugs.
A key question is whether our data may be translated to humans.
Of course, before such a strategy is introduced, our mice findings need to be translated to humans.
We are particularly excited about techniques that can be translated to humans including live animal imaging and whole cell mass cytometry.
If the results can be translated to humans so that the reproductive lives of female humans could be extended and the quality of their eggs maintained as they age, that could avoid lots of medical intervention, she said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com