How activity-dependent changes in Ca2+ are translated to changes in the surface expression of Cl− transporters is not known, although a study in cerebellar GCs suggests that it may involve microRNAs [ 9 ].
How these pathways are deregulated and how changes at the p53 transcription level are translated to changes in the protein and protein phosphorylation, which is required for p53 activation, remains to be understood.
We of course appreciate that further studies are needed, e.g. to investigate whether changes at the mRNA level are translated to changes at the protein level by assessing the protein levels of certain chaperones in different brain regions.
However, for knowledge to be translated to positive practice and sustained behavior change, concerted efforts and long term orientation trainings, follow-up and evaluation is necessary.
The first step of the derivation is to quantify the change in all states x at the end of the pulse perturbation, i.e. at time τ + Δ τ, using the Taylor series expansion: (10) In the next step, the change Δ x is translated to the change in the state x i at time t using the Green's function matrix (GFM) S x (t, τ + Δ τ) [ 47].
These changes were translated to edits operations, and applied to our draft model.
To make the controller robust against parameter variations around an operating point, variations in system parameters due to the load change are translated to the uncertainty framework and are represented using Integral Quadratic Constraints (IQCs).
Overall, in the present study we a) identified a number of novel genetic targets associated with developmental exposure to a sublethal Pb concentration, b) identified enrichment of genes associated specifically with neurite growth and inhibition of LTP and synapse formation at 72 hpf, and c) found that gene expression changes are being translated to the protein level.
Further, it is important to understand how changes in gene expression are translated to rewiring of molecular interactions.
