Moreover, there is evidence that Tau aggregates can be transferred from cell to cell in vitro[ 15- 19].
Enclosed within host cell membranes, amastigotes can be transferred from cell to cell without full exposure to the extracellular milieu, what represents an important strategy developed by the parasite to evade host immune system.
Detailed knowledge of the biological function of circulating miRNA does not exist, however it has been shown that vesicular miRNAs can be transferred from cell to cell and influence the behavior of the recipient cells [ 9].
The fungus can be transferred from cell to cell without exposure to the extracellular milieu; however, the process is still poorly understood and the underlying mechanisms unknown (Alvarez and Casadevall, 2007).
The manuscript makes some progress toward testing the idea that miRNAs can be transferred from cell-to-cell, but given the controversies in the field, a higher standard of proof is required to merit publication in eLife.
In human and mouse cells, cGAMP is transferred from cells to their neighbors by gap junctions, resulting in STING activation and type I IFN production in neighboring cells (Ablasser et al., 2013b).
Moreover, the secreted Scr3 protein was taken up by HeLa cells that were used as recipient cells, suggesting that the Scr3 protein is transferred from cells to cells in a paracrine manner.
While this is also true for most published exosome papers, one expects an eLife paper to propose some explanation for why specific miRNAs are transferred from cell-to-cell according to the exporting cell's KRAS status.
Although TEs are defined as intracellular parasites/entities, they are prone to being transferred from cell to cell, notably in prokaryotes through conjugation of the element or of the plasmids carrying it.
Comparable to prion diseases, in which the pathological prion protein propagates by a seeding/nucleation polymerization process and is transferred from cell to cell, stereotypic spread has been observed in e.g. synucleopathies and Alzheimer's disease [ 21– 21].
