Sentence examples for be too stringent to from inspiring English sources

It may therefore be too stringent to require off-label uses to have the same level of evidence as approved indications.

Thus, this approach may be too stringent to provide the breadth of epitopes required to cover a breadth of HLA types, and additionally faces the difficulty that peptide-based vaccines generally have had poor immunogenicity in humans.

Although the "multiple testing" corrections by False Discovery Rate (FDR) analysis were described in the text and Methods, such criteria may be too stringent to identify differentially expressed genes from treatment groups of FA and low concentration of SWT (Table 1).

It might be too stringent to demand the conservation of the whole hairpin in miRNA identification studies [ 35].

These conservation scores, however, might be too stringent to detect PASs specific to a restricted group of vertebrates such as the mammals.

The low frequency of sustained remission by the Boolean Cr suggests that they may be too stringent to be suitable for long-term studies in clinical practice.

Automakers objected, arguing that the standards were too stringent to meet.

However, when applied to single sample analysis, these criteria were too stringent to detect known differentially methylated regions.

Either the search parameters were too stringent to identify these genes or the chicken sequence was sufficiently divergent to be undetectable in a standard Blast search.

These initial criteria were too stringent to detect Lynch patients in medical practice and were progressively enlarged to include the MSI status of an extended spectrum of tumor types (2).

We found that a simple presence or absence analysis of protein phylogenetic distribution in ciliated and non-ciliated species was too stringent to identify proteins with ciliary function because of false negatives.