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Some pharmaceutical and medical device industry executives have complained that the F.D.A. can be too stringent and nontransparent, discouraging investment in their fields.
However, applying the Bonferroni correction would be too stringent and might falsely reject true effects.
However, there is a growing concern that some structural alerts might be too stringent and that strictly applying them would severely limit the chemical diversity needed to operate drug discovery programs.
Boyer et al. [ 10] noticed that this procedure could be too stringent and allow the insertion of additional edges in the primary graphs.
However, since organismal networks are prone to missing information (edges), the value of γ = 1 could be too stringent, and the algorithm may miss some of the phenotype-related modules.
Although Bonferroni correction is commonly used, it can be too stringent and results in type II errors, and hence the sequential goodness-of-fit (SGoF) method (Carvajal-Rodríguez et al. 2009), which is particularly suited to high-dimensional data, was used to correct for multiple testing for all genetic data.
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European leaders have said that this benchmark is too stringent and needs to be relaxed.
Perhaps the requirement of a proof is too stringent, and perhaps there are other ways of establishing God's existence.
On April 2, 2018, the EPA announced that planned fuel economy increases for cars and light trucks in model years 2022 2025 are too stringent and should be revised.
On April 2, 2018, the US Environmental Protection Agency EPAannouncedced that planned fuel economy increases for model year 2022 2025 cars and light trucks are too stringent and should be revised.
And perhaps critics of the Act — including the op-ed's author — would argue that these steps are too stringent, and make it too hard for active management to occur on wilderness areas.
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CEO of Professional Science Editing for Scientists @ prosciediting.com