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Thus, the observed effect on drug uptake is optimal for phosphocholine-containing truncated sphingolipid analogues, but the N-acyl truncation should not be too rigorous and probably not too small either, since supplementation of natural long-chain SM does not work.
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The act, however, proved controversial, as did his curriculum reforms, which some argued were too rigorous and unrealistic; for instance, five-year-olds were to study fractions.
Classic solutions for the multiple comparisons problem (like Bonferroni correction or FDR) are too rigorous, and clustering-based corrections (grouping of connected individually significant voxels by imposing a single cluster extent threshold) may not be appropriate given the different size of the original ROIs (see Figure 4).
There were arguments at the college and university levels to the effect that this major was too rigorous and would not attract enough interest to make it a viable major.
He has told friends that being Apple's boss would be too rigorous, too all-consuming.
I had the impression that Doorknob's founders, Shannon Gillen and Elisabeth Motley, felt that given their vibrant surroundings, they didn't have to be too rigorous choreographically.
The exam boards select work from random students to scrutinise, but they have a vested interest in schools choosing their syllabi so they are unlikely to be too rigorous.
The Catholic Church has a powerful incentive not to be too rigorous in cleansing its clerical ranks or screening immature seminarians, some of whom may be pedophiles drawn to the priesthood by the delusion that a celibate environment will help them cope with horrible urges.
The assumption of linearity may be too rigorous for any of these situations, especially when using the common 50 k SNP chip.
So don't be too rigorous.
But in the end, Mr. Turner's music may have been too rigorous for Warner Brothers and he isn't the sort who might turn his music around to sell records.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com