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Although integrity is a very important property, it may be too conservative because it ensures the stability of the open-loop systems.
The application of a Bonferroni correction would be too conservative because SNPs within the same locus are highly correlated.
Although the Bonferroni correction might be too conservative because the exposure variables were not independent, chance remains a plausible explanation of the results for the slight increase in OR for some of the exposure variables.
In reality, the range of the data in the ILSI database may also be too conservative, because many varieties are not represented in this database, and studies with some non-transgenic varieties indicate that their composition is frequently outside of this range [ 23].
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First, managers may adopt corporate policies and strategies that are too conservative, because their human capital is invested in the company.
"She will think it's too conservative, because she likes sexy clothes," Ms. Prokopov said, glancing at the Chanel, "but she goes to a lot of official functions, so maybe it will work".
We mention, however, that our alanine scanning strategy may have been too conservative because IM2 is a hydrophobic domain.
One could argue that correcting for the number of pathways even is too conservative, because these particular pathways are not independent entities either (Curtis et al, 2005).
The traditional "genome-wide" significance threshold (p < 5 × 10−8) is too conservative because we are testing fewer variants and we already have prior evidence of association for the lead SNP at the locus from previous studies.
A simple adjustment according to Bonferroni would be too conservative, in part because many of the PRO variables are closely correlated.
One could argue that any such procedure would be too conservative here, not just Bonferroni, because (1) it is likely that the tests are not in fact independent, and (2) we are not exactly sampling from some underlying "true" distribution: what we have a very "closed" system with just so many amino acids and tRNAs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com