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The amino acid change Val60Ala, occurs in B-box1, a conservative change in amino acid sequence that is expected to be tolerated based on SIFT analysis [ 45].
The amino acid change Glu318Gly occurs outside the B-boxes and CCT-domain and was also predicted to be tolerated based on SIFT analysis.
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Nevertheless, as described in this review, pharmacological modulation of disease-associated miRNAs has demonstrated promising therapeutic potential and appears to be well tolerated based on data from short-term studies in animal disease models and human patients.
The programme was well tolerated based on our adverse event assessment and probably offered some benefit to the patients.
An assumption of software fault tolerance techniques is that the probability of having the same fault in multiple variant components is lower, meaning that a fault present in a component should be detected and tolerated based on the behaviour of other variants (Lyu [1996]).
β blockers seem to be safe and well tolerated based on these observational data.
Taken together, the results demonstrate that these 2 formulations of botulinum toxin type A, onabotulinumtoxinA and abobotulinumtoxinA, are safe and well tolerated based on both shorter- and longer-term studies.
If measures are intended to be used in research (as opposed to informing a specific clinical decision), then lower coefficients can be tolerated because conclusions will typically be based on mean scores of many individuals and on multiple studies, both of which serve to reduce measurement variability (Streiner and Norman, 2003).
It is thought that gene dose reductions are tolerated or deleterious based on how out of balance the genome is following a dose change [ 12].
However, ad hominem attacks will not be tolerated, nor will comments that disparage others based on race, gender, sexuality or nationality.
At the White House, spokesman Jay Carney welcomed the Russians' engagement in the Syria crisis, but warned that "further actions based on John Kerry's remarks will not be tolerated".
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