However, it should be noted that as we only looked at carbon source perturbations there were only small changes in the fluxes towards amino acids, and hence these results may not be suitable to dissect whether there is transcriptional control of fluxes towards amino acid biosynthesis.
Based on the above, it will be vital to dissect whether promising therapeutic approaches in the cancer cachexia mouse models could be beneficial in HD, as they may well share common features of muscle wasting syndrome (Fig. 1).
Future study of intermediary metabolic flux alterations by isotopic profiling in both mutant types will be necessary to dissect whether the direction, rather than mere occurrence, of transcriptional alterations in multiple metabolic pathways is indicative of a specific adaptive response to primary mitochondrial dysfunction.
Future studies will be necessary to dissect whether increased H3K56 acetylation also contributes to the hematopoietic phenotypes observed in this study.
It is however known that Hes-1 is particularly sensitive to mitogenic stimulation and further studies are required to dissect whether some of the effects reported here in part might be a consequence of MAP kinase activation.
Future work is clearly needed to dissect whether InlA and/or InlB could play different roles outside and inside the host cell, as it occurs with ActA.
Therefore, expression studies are essential in order to dissect whether their elevated levels are related to CLL biology or merely represent a consequence of other stimuli within CLL microenvironment [ 28].
To dissect whether this is due to reduced PKD activity or can be attributed to inhibitor off-target effects, we examined the effect of PKD2 depletion on cell cycle progression.
To dissect whether EMT is directly involved in MTA resistance, H358_R, A549_R and H460_R were analyzed for their response to MTA with or without SB431542.
In this study, in the attempt to dissect whether TRBP is responsible for the incorporation of guide strand to the protein constituents of RISC, we found that TRBP could be incorporated into the RISC captured by both strands of siRNA duplex in the presence or absence of their target RNAs in the cells, suggesting that TRBP does not influence the selection of guide strand.
