Human-verified examples from authoritative sources
Exact Expressions
1 human-written examples
A hub gene, that is a gene which is among the most highly connected within a module, is likely to be tightly involved in the regulatory mechanisms of all those genes with which it is tightly co-expressed.
Human-verified similar examples from authoritative sources
Similar Expressions
59 human-written examples
Apart from its involvement in invasion and metastasis of cancer, HPA is tightly involved in angiogenesis, primarily by means of releasing heparin-binding angiogenic factors sequestered by HS in BM and ECM, such as basic fibroblast growth factor, vascular endothelial growth factor, keratinocyte growth factor and hepatocyte growth factor [ 29, 30].
Native defects in α-MgAgSb are frequently reported experimentally and are tightly involved in the thermoelectric properties of α-MgAgSb.
Nevertheless, the strong coupling between plants and soil microbes in the top soil under frequent water inputs may have favored the activity of fungi that are tightly involved with roots, resulting in increased dominance.
Clinicians therefore are tightly involved in the delivery of CBRC, whether as service providers or service facilitators, and have a unique ethical responsibility to ensure that appropriate standards of care are provided to all those receiving treatment, be they patients or third-party providers.
Thus, LRP1 is tightly involved in the control of growth regulating signaling processes that involve TGFβ, PDGF, and their receptors.
This event is expected to be related with Rho and Rac small G-protein activities, which are tightly involved in the initiation and expansion of AJ (59).
Because CDT2 is tightly involved in the initiation of DNA replication and cell cycle regulation, and probably deregulated CDT2 expression could promote carcinogenesis accompanying genomic instability, these considerations strongly support the possibility that CDT2 could be a plausible transcriptional target of E2Fs.
This further support the model we proposed several years ago where the assembly of the prion Ure2p is driven by the establishment of intermolecular interactions between the N- and C-terminal domains of two consecutive Ure2p dimers and where the functional C-terminal domain of the protein is tightly involved in the fibrillar scaffold.
Because Boucher et al. reported that LRP1 is tightly involved in the pathogenesis of atherosclerosis by regulating signaling of TGFβ and PDGF, and their receptors [27], [28], knockdown analysis using LRP1 siRNAs was perfomed to examine the role of LRP1 in the regulatory effect of PDGF-induced Col4 expression and PDGF-activated TGFβ signaling pathway in MCs.
Moreover, a recent study showed the hippocampus is tightly involved in the retrieval of remote memory.
Show more... Source & Trust
85%
Authority and reliability
Real-world application tested
The phrase "be tightly involved" functions as a predicate adjective , describing the state of being engaged or participating closely in a particular activity or process. As Ludwig AI shows, this phrase connects a subject with its degree of engagement.
Expression frequency: Rare
