While the work of Groves and others in recent years has demonstrated the importance of protein and lipid spatial organization within cellular membranes, details as to how spatial organization is tied to function are scarce primarily because of the limitations of optical microscopy at length scales below the 250 nanometer diffraction limit.
Additional genetic epistasis analysis indicates that the molecular mechanism of pch-2 in worm longevity is tied to functions of the sirtuin family, implying that pch-2 is another chromatin regulator for worm longevity.
It is also worth considering that transcripts degrade at variable rates that can be tied to biological function, with transcripts supporting immune function, for example, degrading very quickly (Gallego Romero et al. 2014).
Agency, personal responsibility and so on can all be tied to brain function, but these are brain functions that are so staggeringly complex that there is no danger that they're going to be reduced to some simple reflex anytime soon, if ever.
Rather, foundation initiatives should be tied to business functions.
The damage sensitivity of strains deleted for several subunits in four out of five complexes demonstrates that the role of Anc1 in survival after DNA damage is likely to be tied to the functions of at least four of its protein complexes.
These effects appear to be tied to tissue-dependent function of SHARP proteins, e.g. in the forebrain clock.
In fact, disagreement over assigning functions to cortical areas does exist, with some arguing that function may be tied to elements of experiment design [ 64].
Gestures occur frequently across the lifespan suggesting that gesture's function may not be tied to some language or cognitive capacity associated with a particular developmental stage or age group (McNeill, 1992).
Other Lbx2 genes, however, may have retained aspects of ancestral Lbx expression and function, which seems to be tied to the formation of specific neural and muscle cell types.
Network structure has been tied to cellular function from since the discovery of the link between degree and essential proteins in the yeast interactome [ 8].
