Sentence examples for be the upstream regulator from inspiring English sources

The activity of DGAT1 was proposed to be regulated by post-translational modification (Yu et al. 2002) and PKA might be the upstream regulator (Haagsman et al. 1981 , 1982 Rodriguez et al. 1992).

Based upon our data, it is possible that PS2 specific enzymatic activity may be the upstream regulator of the notch pathway in microglia.

In the present study, we found that the expression of ath5 was significantly reduced in the retinas of Atoh8 knock-down zebrafish, suggesting that Atoh8 might be the upstream regulator of ath5 in the retina.

Recent data suggested that microRNA could be the upstream regulator of HIF-1.

A bone morphogenetic protein, BMP2, was predicted to be the upstream regulator for gene expression differences (Table  1).

(25) Thus, FAK/Rho signaling could be the upstream regulator of miR-200c in glabridin-treated MDA-MB-231 and BT-549 cells.

In this study, we have observed that ING4 is the upstream regulator of JWA, and ING4 regulates melanoma angiogenesis through JWA.

Moreover, Tap42-Sit4, whish is the upstream regulator of Gcn4, is indirectly regulated by TORC1. Figure 6 illustrates this signaling pathway, with each element annotated using its information flow rank.

Mutations or RNAi suppression of Ehd1 decreased Hd3a expression under SD conditions, indicating that Ehd1 is the upstream regulator of Hd3a expression [12, 34].

PTEN is the upstream regulator of both PI3K/AKT and MEK/ERK signaling pathways.

PTEN also inhibits the activation of mitogen-activated protein kinase (MAPK), which is the upstream regulator of ERK [33], [34].