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Migraine aura is the cortical phenomenon for which spreading depression is suggested to be the underlying pathophysiological process.
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To establish if this is true, and what might be the underlying genetic or other pathophysiological mechanisms, further research is required".
Although renal vascular disease was thought to be one of the underlying pathophysiological processes in LPHS early on [ 28– 30], more recent renal arteriography studies of patients with LPHS disagree with this hypothesis as the renal vasculature more commonly appears normal [ 4, 27, 31, 32].
If this is the case then almost nothing is known about the underlying pathophysiological processes responsible for this condition and at present there are no effective treatment options.
What could be the underlying mechanism?
Pancreatic fibrosis is a hallmark of the disease, but because of a lack of appropriate in vitro and in vivo models and because repeated tissue samples from patients are not available the underlying pathophysiological mechanisms of disease progression are poorly understood.
Is pulmonary hypertension simply an indicator of the severity of lung injury or is it part of the underlying pathophysiological process contributing to the development of ARDS?
Whilst the diagnostic criteria of TCM have been validated [ 2], the underlying pathophysiological processes still remain unclear.
Some markers can be considered proteins that are relatively easy to detect with this technique, which would account for their frequent observation in proteomic studies on different diseases, while they may not be especially specific indicators for the underlying pathophysiological processes [32].
Descriptive biomarkers are indirect, consequential correlates of the underlying pathophysiological processes.
That this relationship is not replicated in nonseptic patients with clinical evidence of SIRS suggests that the underlying pathophysiological processes are different.
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CEO of Professional Science Editing for Scientists @ prosciediting.com