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It is conceivable that the novel risk markers can also be the underlying pathological mechanisms of the traditional risk factors of diabetic retinopathy, such as abnormal hemostasis and elevated homocysteinemia may be due to prolonged hyperglycemia (i.e., longer duration of diabetes and poor diabetes and blood pressure control).
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What could be the underlying mechanism?
The properties of pain are related to the underlying pathological process, with its location generally indicates where the damage has occurred.
Further investigation is necessary to reveal the underlying pathological process.
Further investigation is necessary to reveal the underlying pathological process and to establish the optimal treatment strategy.
Even though the APR is a non-specific response, it is a feature of clinical scrapie, and due to the high sensitivity of the APR, measurements of APPs could be useful in evaluation of the underlying pathological processes and the systemic involvement of scrapie.
While the pseudohallucinatory percept during the aura (visual or other) is specific of the affected sensory modality and is independent of etiology [9], the spatio-temporal course of aura progression is a clear signature of the underlying pathological process.
As mentioned, these cases do not represent true paediatric PBC, as the underlying pathological process was linked to a genetic deficiency.
Further studies are warranted to better determine the underlying pathological processes that may lead to WMH.
Imaging, biological and genetic biomarkers are valuable parameters to assess the underlying pathological characteristics of the disease.
The underlying pathological process is characterized by neuronal cell death, accompanied by typical neuropathological hallmarks, i.e. extracellular deposits of Aß-peptide and intracellular formation of fibrillar aggregates of abnormally phosphorylated tau protein.
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