Sentence examples for be the underlying pathogenic from inspiring English sources
It is widely believed that MS is an immune-mediated disease whose clinical manifestations and course, as well as response to therapy appear to be heterogeneous, as may be the underlying pathogenic mechanisms [1].
PVD has been previously described by Flammer et al. to be the underlying pathogenic process in NTG [ 10, 73].
There is convincing evidence that STAT4 is a risk locus for SLE in multiple racial groups [ 33, 74], and it may be theorized that interference in type I IFN signalling may be the underlying pathogenic mechanism in this case.
The relative absence of ATP-dependent ion channels and water transporters in astrocytes of the grey matter is thought to be the underlying pathogenic consequence of mitochondrial dysfunction in these areas [78].
The frequent occurrence of scoliosis in patients with CORE Myopathies, supports the thesis that the change in the paravertebral muscle fiber must be the underlying pathogenic factor in scoliosis and may help us understand the onset and progression of curves in patients previously diagnosed with idiopathic scoliosis.
Insulin resistance has been proposed to be the underlying pathogenic link between metabolic syndrome and cardiovascular disease [ 3]; both are associated with a state of low-grade aseptic markers of systemic inflammation, whose pathogenic significance was mostly eclipsed by the vigorous advances in lipid research [ 4].
Dysfunction of cortico-striato-thalamo-cortical circuitry is implicated in OCD, although the underlying pathogenic mechanisms are unknown.
To identify potential therapeutic targets for these debilitating genetic skeletal disorders, current research is focused on understanding the underlying pathogenic mechanisms.
Ever since Knud H. Krabbe described the first five cases of this lysosomal storage disease in 1916 (Krabbe, 1916) much work has been done to determine the underlying pathogenic mechanism of this fatal disease.
The second basis for biomarker research is the identification of proteins representing the host-specific response to a damaging agent usually performed as proteomic approach and better applicable in those cases where the underlying pathogenic agent is not to be anticipated.
