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Although this amyloid cascade hypothesis may be the underlying pathogenesis for the familial form of AD, increasing evidence suggests that oxidative stress has a key role in late-onset sporadic forms, which are the majority of AD cases.
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Axial myopathy can be the underlying cause of rapidly progressive adult-onset scoliosis; however, the pathogenesis of this disorder remains poorly understood.
What could be the underlying mechanism?
It is now assumed that the underlying pathogenesis is inflammatory with unknown etiology.
These studies were not included in this review, for the underlying pathogenesis is obvious.
Functional analysis of mutant gene product is needed to disclose the underlying pathogenesis of CCMC.
Therefore, it is important to find the underlying pathogenesis that links NAFLD to CAD, and to identify the necessary management to prevent and reduce the causes of these two diseases.
Additionally, early life exposures to factors such as microbial toxins, pet dander, and environmental tobacco smoke influence the risk for asthma and related phenotypes in a genotype-specific manner, suggesting that environmental exposures are critical to understanding the underlying pathogenesis of asthma.
GN is a leading cause of human kidney failure, but the underlying pathogenesis is incompletely understood.
Though wide parts of the underlying pathogenesis are still unknown, main components have been described and open up the opportunity for novel therapeutic approaches.
The underlying pathogenesis is unknown, but impairments in certain mitochondrial functions have been found in some CFS patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com