Sentence examples for be the underlying defect from inspiring English sources

It might also be the underlying defect in many cancers.

On the whole, these results suggest that proinflammatory cells and cytokines are markers associated with progression to CCC, whereas the production of IL-10, IL-17 and increased numbers of regulatory T cells are markers of protection from CCC development, indicating that failure to regulate Th1 responses may be the underlying immune defect of patients who progress to CCC.

The same condition did not confer growth advantage to pcp1-18 consistentsistent with the fact that γ-TuC localisation is not the underlying defect in this mutant.

A lower rate of protein synthesis may be the underlying basis for the growth defect documented in kcs1Δ yeast strain [ 13, 15].

Our work strongly suggests that early embryonic cloacal epithelial differentiation defects might be the underlying cause of severe forms of anorectal malformations in humans.

Therefore, basement membrane defects appear to be the underlying cause for the greatly impaired vascularization and trophoblast branching in HAI-1−/− placentas.

What could be the underlying mechanism?

Inherited defects in the peroxisomal transporter ABCD1 is the underlying genetic defect in X-ALD.

Gain-of-function mutations in KCNQ1 are the underlying genetic defect in SQT2.

Transcriptome data is unavailable for MOPD1/TALS, but the underlying defect is suggested to be perturbation of multiple transcripts containing U12-type introns that regulate global cell proliferation (Edery et al, 2011; He et al, 2011).

Insulin resistance is the major underlying defect driving hyperglycemia, the reversal of which is critical to reduce vascular complications and mortality (2).