Sentence examples for be the toxic dose from inspiring English sources
The in vivo antitubercular evaluation in mice models infected with M. tuberculosis revealed 5.67 mg/kg to be the toxic dose of the compounds that proved fatal and highly toxic to mice while LD50 varied from 1.81 to 3.17 mg/kg body weight of the mice.
The dose that shows toxicity signs/morality is the toxic dose and 1/10th of this toxic dose is considered for therapeutic exploration [20].
If at least two out of six patients experienced a DLT, dose escalation had to be stopped and that dose was to be declared the toxic dose.
It was found that the toxic dose of the compounds which proved fatal and highly toxic to mice was 5.67 mg/kg while LD50 varied from 1.81 to 3.17 mg/kg body weight of the mice.
The dose used was twofold below the toxic dose of CDIM9; we therefore estimate a therapeutic index of at least 2, and this may be significantly higher because we did not investigate lower doses of CDIM9.
The starting dose (0.2 mg per day) was based upon the Toxic Dose Low that caused only reversible testicular changes in 4-week toxicology studies in dogs.
The starting dosage of NK105 was 10 mg m−2, which is one-third of the toxic dose low in dogs.
Additionally, no significant pathologic changes were found in the major organs of animals treated with 31.25 mg/kg PNPC and lower doses compared with the control group, so 31.25 mg/kg dose was ruled out as the toxic dose.
Efficacies vary greatly between studies and the dose required is very close to the toxic dose causing clinical symptoms [ 68] including marked anorexia, loss of body weight, dyspnoea, tachycardia, recumbency, torticollis and severe cardiovascular calcifications [ 46, 98, 81, 87].
Although the toxic dose is several grams consumed, precautions should be taken when handling it.[4] Always keep it out of the reach of children and pets and don't absent-mindedly lick it off your fingers!
In infants and small children, studies have indicated that the toxic dose is less than twice the recommended dose.
