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Some of the GDSL enzymes have thioesterase, protease, arylesterase, and lysophospholipase activity, yet they appear to be the same protein with similar molecular weight (∼22 60 kDa for most esterases), although some have multiple glycosylation sites with higher apparent molecular weight.
Though discovered independently, BRCA2 and FANCD1 have been shown to be the same protein.
Sequences with >90% sequence identity were considered to be the same protein, and those ligand-bound and apo structures were compared using PyMOL (Version 1.3, Schrödinger, LLC).
Chen et al (2004) also detected an elevation of a peak at 8930 m/ z in samples from colon cancer patients that may be the same protein.
Based on these two criteria, 112 non-redundant DEPs (the DEPs with the same "hit number" and "score" were considered to be the same protein) were identified when comparing the day 6 group to the day 3 group.
But some of them were unknown proteins that could not be identified, and some of them with different PI and MW finally proved to be the same protein (such as 348 and 429, both identified as tubulin beta), which suggest different post-translational modification.
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Obviously, some different spots in gels were identified to be the same proteins in supplementary Table S (Additional File 1).
It's the same protein".
This is the same protein that piles up in the brains of patients with Alzheimer's disease; microbleeds from amyloid can be associated with dementia.
It was then discovered that a previously identified protein associated with proteolytic degradation, known as ATP-dependent proteolysis factor 1 (APF-1), was the same protein as ubiquitin.
Intriguingly, Lsa24 and LfhA are the same protein, indicating that this single protein is able to bind host factor H, FHR-1 and laminin.
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