Sentence examples for be the relevant target from inspiring English sources
Our finding that Toxoplasma possesses inhibitory effects on total levels of histone H3 Ser10 phosphorylation suggests that this may be the relevant target of suppression.
Studies by Han and Ip [53] have suggested that the homo and heterodimers regulate different sets of genes and consequently either one or both of these NFκB transcription factors could be the relevant target for the Tl pathway in Aβ42 induced neuropathology.
However, with the discovery and validation of NMO-IgG in reductionist in vitro and in vivo models, it has become evident that astrocytic AQP4 may be the relevant target autoantigen in neuromyelitis optica instead of MOG which is expressed by oligodendrocytes [32].
As inhibition of transketolase enzyme reactions suppresses tumour growth and metastasis, TKTL1 could be the relevant target for novel anti-transketolase cancer therapies.
For example in the case of ordering the scaffolds of a genome assembly, the N50 or N90 scaffold size could be the relevant target resolution.
SMOC1 does not have a previously reported function in inflammatory or immune response pathways, and the evidence provided by the chromatin state maps suggests that SMOC1 is unlikely to be the relevant target gene at this locus.
Alternatively, other pre-replicative components, Sld3 Sld7, or other replication-initiation proteins, such as Cdc45, might be the relevant targets of kinetochore DDK for advancing replication timing at pericentromeres.
In contrast, HNSCC frequently display NOTCH loss-of-function-mutations [ 37, 38], thus in HNSCC, other substrates such as Cyclin E, MYC, or mTOR may be the relevant targets for FBXW7.
As yet, however, it is unclear whether HDAC1 and HDAC2, reduced in RA, would be the relevant targets responsible for potential anti-inflammatory effects of HDACi, and whether the residual total HDAC activity present in RA synovial tissue might still play an essential role in cellular activation and survival.
That is, the relevant target proteins for a certain ligand need not be mutually exclusive.
This does not necessarily mean that different histidines are the relevant target of protonation, but that (between strains) variable amino acids in the vicinity of a specific histidine affect its pKa.
