Although direct cytotoxic effects on endothelial cells by Stx are the primary pathogenic event, there is evidence that indicates the inflammatory response mediated by polymorphonuclear neutrophils and monocytes as the key event during HUS development.
It has been proved that H2C2O4 is the primary pathogenic material secreted by S. sclerotiorum [ 22- 24].
Acinetobacter baumannii (25.9%, 7.5% were single bacterial strains), yeast sporophytes and Aspergillus (8.9%) were the primary pathogenic bacteria.
This is a major concern, since progressive β-cell failure is the primary pathogenic abnormality responsible for development of T2DM and progressive HbA1c rise (Fig. 3).
In the general population, macrovascular disease is the primary pathogenic mechanism causing CHD; however, in population with diabetes, it is the microvascular disease, in addition to the macrovascular component, that may play a role in the development of CHD.
In our patient, IgG autoantibody, which binds to RBCs, was detected in our patient using the direct antiglobulin test (Coomb's test), leading us to conclude that AIHA was the primary pathogenic mechanism that resulted in his hemolysis.
B. burgdorferi sensu stricto is the primary pathogen of Lyme disease in the United States and is the only pathogenic genospecies that causes Lyme disease in both North America and Europe.
These ubiquitous skin bacteria may sometimes be the primary, opportunistic pathogenic constituents of CWPBs, as seen in Figures 1 and 2. Resident skin microflora may be considered largely commensal in nature, but it is known that nonpathogenic microbes often become opportunistically pathogenic when the skin barrier becomes impaired [ 47].
EBV was not the primary pathogenic factor in our samples.
Glomerular deposition of circulating IgA immune-complexes is considered the primary pathogenic mechanism [ 38].
