Sentence examples for be the primary defect from inspiring English sources
The authors suggested that defective growth regulation could not be the primary defect in the initiation of cysts, but rather the relationship between proliferation and cyst formation might be indirect.
Altered calcium homeostasis may not be the primary defect in diabetic cardiomyopathy.
As insulin resistance seems to be the primary defect in these patients, this could support our findings of an association between preDM, T2DM and OSA.
Skeletal muscle is responsible for 75% of total insulin-dependent glucose uptake; consequently, skeletal muscle IR is considered to be the primary defect of systemic IR development.
Mitochondrial abnormalities have been documented in insulin-resistant and diabetic states in human and animal studies, and it has been proposed that mitochondrial dysfunction may be the primary defect in obesity-related insulin resistance (Patti and Corvera, 2010).
It has been reported that women with polycystic ovary syndrome have a 30 times higher risk of having sleep-disordered breathing (17); insulin resistance seems to be the primary defect in these women, which is then followed by sleep-disordered breathing.
Based on these data, the phenotype of reduced lipid droplet size, increased lipolysis and reduced TAG storage appears to be the primary defects in the WAT of Fsp27−/− mice, while increased mitochondrial activation and up-regulation of BAT specific markers are secondary effects.
These urothelial abnormalities may be downstream to a more proximal cause or could be the primary defects.
Loss of the DGC from the sarcolemma causes membrane instability, which is the primary defect of dystrophin-deficient muscular dystrophy [21] [23].
These results support the model that ectopic expression of Ubx in Asx homozygous mutant clones is the primary defect leading to wing blade abnormalities [34].
Our results suggest that upregulation of Ubx transforms cells from a wing blade fate to a haltere fate, and that the presence of haltere cells within the wing blade is the primary defect leading to the adult wing phenotypes observed.
