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The inhibition of the BCR-ABL pathway seems to be the predominant effect of Danusertib in BCR-ABL positive cells in vitro, at least at low nanomolar concentrations.
As most of the functional sites are formed by short seed sites, one can infer marginal reduction of the mRNA level to be the predominant effect of global miRNA-mediated regulation.
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Experimental studies have shown that the scCO2 extraction of MMA is the predominant effect as compared to the enhanced polymerization due to plasticization.
In this study, we found that the 5-HT1A-mediated decrease of intrinsic excitability is the predominant effect of 5-HT in PFC pyramidal neurons from young adult rats (∼4 wk), while the 5-HT2-mediated increase of intrinsic excitability is the predominant effect of 5-HT in PFC FS interneurons.
Bone resorption (catabolic effect) is the predominant effect when PTH is chronically elevated by continuous infusion.
These results clearly suggest that inhibition is the predominant effect of elevated extracellular Mg++ in the intact network.
He et al. [ 36] showed that hydrogen bonding is the predominant effect in the interactions between gallotannins and carbohydrates.
While cell death is the predominant effect of mitochondrial dysregulation, mitochondrial fragmentation may have a less dramatic chronic impact under certain circumstances.
IGFs mediate proliferation and survival, and although it is unclear which is the predominant effect in vivo, it is probable that both are important even though their contribution may depend on the stage of development.
The results described below were the predominant effects observed in multiple fields of cells.
Debate continues as to whether allopatric speciation or peripatric speciation through a founder effect is the predominant force driving evolution in vertebrates.
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CEO of Professional Science Editing for Scientists @ prosciediting.com