Sentence examples for be the physiological substrate from inspiring English sources
While histone H3 may not be the physiological substrate of Plk1 and Aurora A in vivo, our finding are consistent with a delay and decrease of Aurora A and Plk1 mitotic kinase activity in Tim depleted cells.
Hence, sumoylated PCNA appears to be the physiological substrate of Rad18, and the modification not only recruits Srs2 and potentially Elg1, but it also facilitates damage-induced ubiquitylation.
Sustained discharge of neuronal circuits is thought to be the physiological substrate that mediates on-line maintenance and manipulation of information performed by the PFC [ 1, 2].
However, the most robust substrate so far reported for aprataxin is adenylated DNA, in which AMP-linked to the 5′-terminus of single- or double-stranded DNA breaks, suggesting that this may be the physiological substrate for this enzyme [8].
It was therefore predicted that Bvu0219 would oxidize a monosaccharide to the corresponding lactone and that the product of the reaction catalyzed by Bvu0219 would be the physiological substrate for the lactonase activity of Bvu0220.
The apparent kcat/ Km value for ATP−pyrophosphate exchange activity for d, l- N-acetylphosphinothricin was 3.5 μM−1 min−1, whereas the kcat/ Km,app for l- N-acetyldemethylphosphinothricin was 0.5 μM−1 min−1, suggesting the former might be the physiological substrate.
No interaction partners for cADO have been identified and the enzyme does not appear to be membrane associated; however, it seems unlikely that cytosolic long-chain aldehydes would be the physiological substrates for cADO because of their extremely low solubilities.
This observation supports the hypothesis that pAp is the physiological substrate of Cv1693.
The kinetic parameters for this reaction (kcat/ Km = 1.6 × 10 M–1 suggestggesthatat UDP-diNAcBac is the physiological substrate.
Since Hcy is the physiological substrate of CBS [ 9], depletion of CBS can be expected to increase the levels of Hcy.
The lower Km,app for AcPT may indicate that this compound is the physiological substrate for PhsA, provided that free AcDMPT and AcPT are both biosynthetic intermediates (i.e., that the P-methyltransferase PhpK acts on AcDMPT in solution).
